By Michael B. M.D. Fossel
Far from simply sharing a standard onset overdue within the lifespan, age-related illnesses are associated by way of basic universal features on the genetic and mobile degrees. Emphasizing human cellphone mechanisms, the 1st part provides and analyzes our present knowledege of telomere biology and mobilephone senescence. In great educational aspect, the textual content brings the reader modern on telomere upkeep, telomerase dynamics, and present study on phone senescence--and the overall model--cell senescence because the critical part in human senescence and melanoma. for every human malignancy, the bankruptcy stories and analyzes all to be had info on telomeres and telomerase, in addition to summarizing present paintings on their scientific program in either analysis and melanoma therapy.
The moment variation, orientated by means of organs and tissues, explores the particular physiological effect of phone senescence and getting older on medical illness. After a precis of the literature on early getting older syndromes--the progerias--the textual content reports getting older illnesses (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune getting older, presbyopia, sarcopenia, etc.) within the context of the tissues during which they happen. all the ten medical chapters--skin, cardiovascular process, bone and joints, hematopoetic and immune structures, endocrine, CNS, renal, muscle, GI, and eyes--examines what we all know in their pathology, the function of mobilephone sensescence, and clinical interventions, either present and potential.
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Cells, Aging, and Human Disease by Michael B. M.D. Fossel